Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacin in Pigs
نویسندگان
چکیده
Enrofloxacin (ENR) is an antimicrobial agent belonging to the group of third-generation fluoroquinolones (FQs) [1,2]. ENR has been historically used as veterinary medicine for treatment of gastrointestinal and respiratory infections in several animal species, including pigs cursing diseases caused by gram-positive and negative bacteria. In animals, ENR is de-ethylated to its primary metabolite ciprofloxacin (CPX), and both molecules are effective against microorganisms which are resistant to other antimicrobial agents, such as aminoglycosides, tetracyclines, macrolides and β-lactams [3-9].
منابع مشابه
Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs
A new, more palatable formulation of 10% enrofloxacin enteric-coated granules was investigated to evaluate the pharmacokinetic effect in plasma, the residue elimination in tissues and the clinical efficacy against Actinobacillus pleuropneumonia (APP) and Mycoplasam suis (MS) in pigs. In this study, the enrofloxacin concentrations in plasma and tissues were detected using high-performance liquid...
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